PI-083, a new platelet aggregation inhibitor.

PI-083, a new platelet aggregation inhibitor.

Mariannaepyrone--a new inhibitor of thromboxane A2 induced platelet aggregation.

Mariannaeapyrone ((E)-2-(1,3,5,7-tetramethyl-5-nonenyl)-3,5-dimethyl-6-hydroxy-4H-pyran-4-one) is a new fungal metabolite isolated from fermentations of the common mycophilic deuteromycete Mariannaea elegans. The chemical structure of the 4-pyrone was determined by spectroscopic techniques. Mariannaeapyrone is a selective inhibitor of the thromboxane A2 induced aggregation of human platelets, w...

Endogenous inhibitor (s) of platelet aggregation.

Human blood plasma contains an endogenous inhibitor (s) of platelet aggregation (EIPA). The EIPA activity was found to be associated with a globulin-rich and albumin-rich protein fractions of blood plasma. Data presented in this paper suggests that ELPA may regulate platelet aggregation associated with excessive production of arachidonic acid metabolites (JPMA 35 41, 1985).

Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717.

A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydrooxazine-2,5-dione by NMR analysis, X-ray crystallographic analysis and chemical synthesis. Bassia...

Novel Platelet Aggregation Inhibitor Produced by Chromobacterium sp . QS 3666

A novel platelet aggregation inhibitor, YM-254890, was isolated from the culture broth of strain QS3666. This strain was isolated from a soil sample collected at Okutama, Tokyo, Japan, and was identified as Chromobacterium sp. by morphological and physiological criteria. YM254890 was purified from the culture supernatant by solvent extraction, ODS and silica gel flash chromatography, followed b...